Pacientes com muitas formas de imunodeficiências primárias apresentam risco aumentado de malignidades secundárias a uma série de fatores diferentes, incluindo desregulação imunológica, predisposição genética, sensibilidade à radiação e eliminação viral prejudicada.
A utilidade clínica deste painel é:
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Chinn, I. K., Chan, A. Y., Chen, K., Chou, J., Dorsey, M. J., Hajjar, J., Jongco, A. M., 3rd, Keller, M. D., Kobrynski, L. J., Kumanovics, A., Lawrence, M. G., Leiding, J. W., Lugar, P. L., Orange, J. S., Patel, K., Platt, C. D., Puck, J. M., Raje, N., Romberg, N., Slack, M. A., … Walter, J. E. (2020). Diagnostic interpretation of genetic studies in patients with primary immunodeficiency diseases: A working group report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma & Immunology. The Journal of allergy and clinical immunology, 145(1), 46–69. https://doi.org/10.1016/j.jaci.2019.09.009
